Principal Scientist / Sr. Scientist II, Hematology (Non-Onc)
Company/Institution: |
BioMarin Pharmaceutical Inc. |
Department: |
Research & Development |
Location: |
Novato, CA, USA |
Degree Requirements: |
PhD and/or MD |
Salary: |
Not available |
Job Type: |
Other |
Posted: |
April 7, 2021 |
Job Setting: |
Corporate (Biotech or Pharmaceutical) |
Application Period: |
April 7-June 1, 2021 |
The Biology Research group at BioMarin is seeking a Principal / Sr. Scientist with extensive experience researching genetic / inherited non-maliganant hemotology disorders using a broad range of in vitro and in vivo models, particularly in the context of evaluating novel therapeutic approaches.
The Principal / Sr Scientist will assume a crucial role in developing novel therapeutic concepts and will contribute at all stages of a project, from inception, early project validation, optimization, candidate selection and through to early clinical development of novel medicines for patients with rare inherited hematological disorders. He/She will work collaboratively with other teams to develop project strategy, identify key drug discovery issues, propose and implement creative solutions, execute and guide teams to success and decision points. He/She will lead the early development of a pipeline program targeting a genetic hematological disease, including formation of a cross-functional program team and, in partnership with the team, building short- and long-range plans and establishing key go/no-go decision-making criteria.
In addition to leading the early program team, the Principal / Sr Scientist will be a key scientific leader in the group, interfacing with program teams developing other novel therapeutics for inherited hematological diseases and will play a leadership role in helping to set the strategic direction for BioMarin’s interest in genetic hematological diseases, including the assessment of new target/therapeutic concepts and the evaluation of potential business development opportunities. The Sr/Principal Scientist will also manage several direct reports.
The successful candidate will have a strong background in hematology research, with demonstrated research experience in the application of novel therapeutic paradigms for genetic hematological diseases. Experience in the clinical practice will be beneficial.
The successful candidate will have experience providing context of findings to senior management and offering insights to inform continued clinical development of programs for inherited hematological (non-onc) diseases. The candidate will communicate, publish, and present scientific data and conclusions, along with their potential translatability to humans, to project teams, external collaborators, and the scientific community.
RESPONSIBILITIES:
Conduct early research for genetic non-malignant hematologic disorders
Develop novel programs based on innovative, ground-breaking discoveries that could lead to new, high-impact therapeutic opportunities for patients with unmet medical need
Lead a cross-functional preclinical program team in the development of a novel therapeutic for inherited hematological diseases
Lead a team of scientists to investigate the mechanisms of action of therapeutics for inherited hematological diseases
Direct research and publish findings in high-impact journals and present research at major conferences
Effectively partner with the program team, other scientists and the Research and Early Development leadership team to develop and execute on the program’s strategic plan
Present program data at a range of internal forums, including Research Seminars and Leadership Team governance forums
Provide senior scientific leadership and guide the strategic direction of the company’s efforts in the non-onc hematology therapeutic area, including developing and evaluating new internal and external therapeutic opportunities
Manage, mentor and guide a focused team of in vitro / in vivo scientists
Review and contribute to study synopses, protocols, study reports and regulatory documents
Collaborate with various BioMarin functions, CROs, university or analytical laboratories, business partners, as necessary to ensure appropriate/timely progression of projects
Participate in multi-disciplinary drug development teams and may lead sub-teams
Excellent written and verbal communication skills
Ability to build/foster productive cross-functional collaborations both within and external to BioMarin
EDUCATION:
Required: M.D. or PhD in hematology (non-onc) or immunology. Experience in the field of pharmacology, viral gene therapy, non-viral gene therapy or a related subject area.
EXPERIENCE:
8+ (Sr Scientist 2) or 10+ (Principal Scientist) years of experience in the research of genetic hematological diseases and novel therapeutic approaches in an academic or industrial setting; clinical practice experience in non-onc hematology is a plus
The candidate will have a proven record of accomplishment of driving and supporting multiple research projects, and contributions as an author to high-impact, peer-reviewed publications in the field
Experience in performing in-depth functional assays and in vivo efficacy studies for hematological conditions
Experience supporting the development of gene therapies, small molecules, biologics and/or other therapies, including determining non-clinical program strategy and design.
Clinical trial design experience to guide seamless transition of early pipeline projects into clinical development
Strong critical, scientific, and strategic thinking skills; Strong problem solving and decision-making abilities
Strong communication (verbal and written) skills
Experience and ability to work collaboratively in cross-functional teams
About the Employer
BioMarin is the world leader in delivering therapeutics that provide meaningful advances to patients who live with serious and life-threatening rare genetic diseases. We target diseases that lack effective therapies and affect relatively small numbers of patients, many of whom are children. These conditions are often inherited, difficult to diagnose, progressively debilitating and have few, if any, treatment options. BioMarin will continue to focus on advancing therapies that are the first or best of their kind.
BioMarin’s Research & Development group is responsible for everything from research and discovery to post-market clinical development. Research & Development involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with rare diseases. Come join our team and make a meaningful impact on patients’ lives.
We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, sexual orientation, national origin, disability status, protected veteran status, or any other characteristic protected by law.
How to Apply
https://careers.biomarin.com and/or hit APPLY NOW button below
Contact Information
Anya Louisa
105 Digital Drive
Novato, CA 94949 USA
anya.louisa@bmrn.com
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