University of Pennsylvania
Division of Hematology-Oncology
Philadelphia, PA, USA
November 22, 2020
November 1-December 31, 2020
A full-time postdoctoral position is available in the Paralkar Lab in the Division of Hematology-Oncology and the Abramson Family Cancer Research Institute at the University of Pennsylvania for an NIH-funded project to study ribosomal RNA transcription in hematopoiesis.
Our laboratory combines cutting-edge molecular biology approaches with in vitro and in vivo models of hematopoiesis and leukemogenesis to dissect how key hematopoietic transcription factors bind to ribosomal DNA and fine-tune the transcription of ribosomal RNA, the most abundant RNA in the cell, to meet precise ribosome requirements of diverse blood cell types. This work is funded by an R35 grant from NIGMS (NIH). Experimental techniques used in our work include: Human and mouse hematopoietic and leukemia models, chromatin studies including ChIP and chromosomal looping assays, FISH and nucleolar imaging, chromatin proteomics, high-throughput sequencing approaches including ATAC-Seq, ChIP-Seq, RNA-Seq, and a variety of molecular assays.
Candidates must have a PhD degree, and proficiency with molecular biology and cell biology techniques. Experience in the epigenetics/chromatin/transcription arena is strongly favored. Experience with mouse hematopoiesis or mouse models of leukemia is a plus, but is not required.
Please send a CV, a brief cover letter summarizing past research and career goals, and the names and contact information of three references to: firstname.lastname@example.org
Philadelphia, AL 19104 USA
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