Computational Immunology PhD

Company/Institution:	Boston Children's Hospital
Department:	Pediatrics
Location:	Boston, MA, USA
Degree Requirements:	PhD	Salary:	$50,000 - $99,999
Job Type:	Research	Posted:	November 18, 2025
Job Setting:	Non-Profit Research Institute	Application Period:	November 18-December 18, 2025

The Dana-Farber/Boston Children’s Cancer and Blood Disorders Center is seeking an experienced computational immunology PhD to join our Division as an Instructor in Pediatrics.  This position is focused on investigating the immunology of complex preclinical and clinical systems with relevance to hematopoietic stem cell transplant (HCT) and cellular therapies.  The successful applicant will play a key role in the development and implementation of new analysis pipelines, driving thoughtful experimental designs, analyses and inferences throughout the field of HCT and cancer immunotherapy. 

We are looking for a talented person with extensive experience in NGS data analysis, proficiency in R and Python, experience in the application of machine learning methods, and specific expertise in computational immunology. As a part of this position the successful candidate will collaborate closely with members of the Division of Hematology/Oncology, the Dana-Farber/Boston Children’s Cancer and Blood Disorders faculty and mentor research associates, graduate students, and post-doctoral fellows in computational immunology techniques.  This position is considered a pathway to independence, and the successful candidate is expected to obtain grants, demonstrate continued research productivity and initiate an independent job search within 2 years of accepting the position. 

Experience with scRNA-Seq, ATAC-seq, deep TCR sequencing analysis in mouse models, non-human primates, and human data is required. The successful applicant will focus on developing novel integrative analysis strategies for large “omic” data sets, including the above.

Position Requirements:

•    PhD in bioinformatics, computational biology, genetics, statistics or equivalent experience; alternatively, a PhD in molecular biology, immunology, or cancer biology with a very strong publication record demonstrating bioinformatics expertise and the ability to perform high throughput data analyses

•    Experience analyzing NGS sequencing data and familiarity with genomics data processing pipelines

•    Strong background in statistical analysis of genomic/high-throughput sequencing data

•    Experience in data analysis, interpretation, and effective visualization of large datasets

•    Fluency in R, and Python with an emphasis on NGS analysis

•    Collaborative development skills using version control systems (e.g. Git)

•    Experience with common databases and genome browsers (e.g., Ensembl, IGV, UCSC)

•    Ability to work independently and as a member of a multifunctional analytical team in a fast-paced environment

•    Strong organizational and interpersonal, verbal, and written communications skills

•    Domain knowledge in immunology and cancer biology and relevant experimental techniques (e.g., flow cytometry, immune sequencing, RNA-seq, ATAC-seq)

About the Employer

The Dana-Farber/Boston Children’s Cancer and Blood Disorders Center has a faculty numbering more than 100, with exceptional research and clinical programs in non-malignant hematology, hematologic malignancies, solid tumors, and neuro-oncology.

Interested candidates should submit a curriculum vitae, a statement of interest, and three letters of recommendation to: 

David A. Williams, MD, Chief, Division of Hematology/Oncology, President, Dana-Farber/Boston Children’s Cancer and Blood Disorders Center

and

Leslie S. Kean, MD, PhD

Director, Hematopoietic Stem Cell Transplant Program

Dana-Farber/Boston Children’s Cancer and Blood Disorders Center

c/o Trishna Rana

Boston Children’s Hospital

300 Longwood Avenue

Boston, MA 02115

Trishna.Rana@childrens.harvard.edu

Boston Children’s Hospital and Children’s Hospital Pediatric Associates, Inc. are an Equal Opportunity / Affirmative Action Employer. Qualified applicants will receive consideration for employment without regard to their race, color, religion, national origin, sex, sexual orientation, gender identity, protected veteran status or disability.

Contact Information

Trishna Rana
300 Longwood Ave
Boston, MA 02115 USA
trishna.rana@childrens.harvard.edu

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