In Vivo Pharmacology Research Scientist

Company/Institution: Vertex Pharmaceuticals
Department: Cell and Genetic Therapies
Location: Boston, MA, USA
Degree Requirements: PhD Salary: $100,000 - $149,999
Job Type: Research Posted: September 14, 2021
Job Setting: Corporate (Biotech or Pharmaceutical) Application Period: September 14-November 15, 2021

Vertex is seeking a Pharmacology Research Scientist to manage and run In Vivo studies to support our Hemoglobinopathies program, specifically for Sickle Cell Disease and Beta Thalassemia. KEY RESPONSIBILITIES: Design, execute, interpret, and manage research and IND-enabling in vivo pharmacology studies to evaluate efficacy, pharmacokinetic, pharmacodynamic, tolerability and mechanism of action of novel therapeutics, Contribute to in vivo model development and characterization internally as well as at CROs, Maintain good documentation practices, Analyze and present scientific data in matrixed team settings, and keep up with relevant scientific literature, Effectively collaborate with a fully integrated team to facilitate the success of projects, Perform advanced and/or complex experimental troubleshooting, Independently prepares study presentations and presents experimental conclusions at internal Group/Department or Project Team research meetings REQUIREMENTS: PhD Required, Understanding of drug discovery, applied pharmacology, and drug development, Experience in design and execution of well-controlled in vivo pharmacology studies to demonstrate proof-of-concept in preclinical models, Previous experience in hemoglobinopathies or rare blood disorders is required, Previous experience with ex vivo techniques including Flow Cytometry is required, Experience with humanized mouse models is a plus., Familiarity of good documentation standards to support regulatory filings, with experience in gene therapy, Excellent communication skills with the proven ability to work effectively as a member of a multidisciplinary team, Demonstrates awareness of other Project-related disciplines and an understanding of general concepts and some experimental detail within those.

About the Employer

In June 2019, Vertex announced the establishment of a new research site in the Boston area where research, development, and clinical manufacturing for cell and genetic therapies will be primarily based. Cell and genetic therapies represent two rapidly emerging therapeutic modalities with the potential to treat—and even cure—several of the diseases Vertex is focused on, including sickle cell disease, Duchenne muscular dystrophy and type 1 diabetes. Further investment in a research site specifically designed to advance these programs will be key to Vertex’s continued and sustained leadership in these exciting approaches. At Vertex Cell and Genetic Therapies (VCGT) our research teams will bring together the best biology, technologies and enhanced manufacturing capabilities to ensure we bring these cutting-edge transformative therapies to patients as quickly as possible.

How to Apply

Please apply directly through Workday using the application link.

Contact Information

Akila Shanmugaraj
50 Northern Ave
Boston, MA 02210 USA

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